Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications
نویسندگان
چکیده
Understanding the interaction between biomaterials and blood is critical in design of novel for use biomedical applications. Depending on application, can be designed to promote hemostasis, slow or stop bleeding an internal external wound, prevent thrombosis permanent temporary medical implants. Bacterial nanocellulose (BNC) a natural, biocompatible biopolymer that has recently gained interest its potential blood-contacting applications (e.g., artificial vascular grafts), due high porosity, shapeability, tissue-like properties. To BNC been modified through oxidation functionalization with various peptides, proteins, polysaccharides, minerals interact coagulation cascade. For as graft vascularization, extensively researched, studies investigating different modification techniques enhance endothelialization such functionalizing adhesion peptides extracellular matrix (ECM) proteins well tuning structural properties surface roughness, pore size, fiber size. While inherently exhibits comparable mechanical characteristics endogenous vessels, these enhanced chemical altering fabrication method. In this review, we provide comprehensive overview have implemented suitability testing applied evaluate their performance. Initially, focused hemostatic Subsequently, outline methods used production BNC-based grafts generate vasculature tissue engineered constructs. This sequential organization enables clear concise discussion modifications highlights diverse versatile nature natural biomaterial.
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ژورنال
عنوان ژورنال: ACS Materials Science Au
سال: 2023
ISSN: ['2694-2461']
DOI: https://doi.org/10.1021/acsmaterialsau.3c00021