Balance Between Rapid Delayed Rectifier K + Current and Late Na + Current on Ventricular Repolarization
نویسندگان
چکیده
منابع مشابه
Characterization and functional consequences of delayed rectifier current transient in ventricular repolarization.
Although inactivation of the rapidly activating delayed rectifier current (I(Kr)) limits outward current on depolarization, the role of I(Kr) (and recovery from inactivation) during repolarization is uncertain. To characterize I(Kr) during ventricular repolarization (and compare with the inward rectifier current, I(K1)), voltage-clamp waveforms simulating the action potential were applied to ca...
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Proarrhythmia has been observed with the antipsychotic agent thioridazine (THIO). The mechanisms underlying these effects are unknown. The objectives of this study were 1) to characterize the effects of THIO on cardiac repolarization and 2) to determine whether lengthening of the Q-T interval could be explained by blocking major K+-repolarizing currents. Isolated, buffer-perfused guinea pig hea...
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ژورنال
عنوان ژورنال: Circulation: Arrhythmia and Electrophysiology
سال: 2020
ISSN: 1941-3149,1941-3084
DOI: 10.1161/circep.119.008130