Basal Ganglia Calcification Is Associated With Local and Systemic Metabolic Mechanisms in Adult Hypoparathyroidism
نویسندگان
چکیده
Abstract Context Hypoparathyroidism is characterized by low serum calcium, increased phosphorus, and inappropriately or decreased parathyroid hormone, which may be associated with soft tissue calcification in the basal ganglia of brain. Objective To assess prevalence factors involved pathophysiology (BGC) brain chronic hypoparathyroidism to evaluate proposed pathophysiologic mechanisms. Design Case-control study retrospective review medical records over 20 years. Setting Single academic center. Patients 142 patients computed tomography (CT) head scans followed between January 1, 2000 July 9, 2020, 426 age- sex-matched controls CT same interval. Interventions None. Main Outcome Measures Demographic, biochemical, imaging findings, semiquantitative assessment volumetric BGC. Results The found that 25.4% for a median 17 years after diagnosis had BGC, developed at younger age than controls. BGC was 5.1-fold more common nonsurgical less postsurgical patients. Low calcium calcium/phosphate ratio correlated Neither phosphorus nor × phosphate product predicted Lower greater volume extent varied widely, generally having distribution calcification. Conclusions ratio, related severity disease, its etiology, duration treatment.
منابع مشابه
Basal ganglia calcification in idiopathic hypoparathyroidism
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology and Metabolism
سال: 2021
ISSN: ['1945-7197', '0021-972X']
DOI: https://doi.org/10.1210/clinem/dgab162