Bayesian Adaptive Methods for Clinical Trials
نویسندگان
چکیده
منابع مشابه
Bayesian Adaptive Methods for Clinical Trials of Targeted Agents
This chapter presents general Bayesian concepts and some specific designs for human clinical trials of targeted agents. The designs employ decision rules that use each patient’s protein or gene expression biomarkers, and possibly conventional prognostic variables, to choose an individualized treatment regime that may include one or several targeted agents. The Bayesian rules are sequentially ad...
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A Bayesian adaptive design is proposed for a comparative two-armed clinical trial using decision theoretical approaches. A loss function is specified to consider the cost for each patient, and the costs of making incorrect decisions at the end of a trial. At each interim analysis, the decision to terminate or to continue the trial is based on the expected loss function while concurrently incorp...
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While randomisation is the established method for obtaining scientifically valid treatment comparisons in clinical trials, it sometimes is at odds with what physicians feel is good medical practice. If a physician favours one treatment over another based on personal experience or published data, it may be more appropriate ethically for that physician to use the favoured treatment, rather than e...
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While randomization is the established method for obtaining scientifically valid treatment comparisons in clinical trials, it sometimes is at odds with what physicians feel is good medical practice. If a physician favors one treatment over another based on personal experience or published data, it may be more appropriate ethically for that physician to use the favored treatment, rather than enr...
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Development of treatments for rare diseases is challenging due to the limited number of patients available for participation. Learning about treatment effectiveness with a view to treat patients in the larger outside population, as in the traditional fixed randomised design, may not be a plausible goal. An alternative goal is to treat the patients within the trial as effectively as possible. Us...
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ژورنال
عنوان ژورنال: Journal of Statistical Software
سال: 2010
ISSN: 1548-7660
DOI: 10.18637/jss.v037.b01