Behavioral Models of Tinnitus and Hyperacusis in Animals

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Behavioral Models of Tinnitus and Hyperacusis in Animals

The phantom perception of tinnitus and reduced sound-level tolerance associated with hyperacusis have a high comorbidity and can be debilitating conditions for which there are no widely accepted treatments. One factor limiting the development of treatments for tinnitus and hyperacusis is the lack of reliable animal behavioral models of these disorders. Therefore, the purpose of this review is t...

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Phenotypic Characteristics of Hyperacusis in Tinnitus

BACKGROUND Many people with tinnitus also suffer from hyperacusis. Both clinical and basic scientific data indicate an overlap in pathophysiologic mechanisms. In order to further elucidate the interplay between tinnitus and hyperacusis we compared clinical and demographic characteristics of tinnitus patients with and without hyperacusis by analyzing a large sample from an international tinnitus...

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Pathology of Tinnitus and Hyperacusis-Clinical Implications

Not long ago, tinnitus and hyperacusis were considered intractable symptoms and the lack of interest and shortage of research in diseases with these symptoms would have made publishing a special issue on tinnitus and hyperacusis nearly impossible. During the past two decades, there has been an explosion of research on tinnitus and incremental growth on hyperacusis, a condition associated with h...

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Central Gain Control in Tinnitus and Hyperacusis

Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural activity transmitted from the cochlea to the central auditory system. Despite a reduced cochlear output, neural activity from more central auditory structures is paradoxically enhanced at suprathreshold intensities. This compensatory increase in the central auditory activity in response to the loss of senso...

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Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia

INTRODUCTION Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined. PATIENTS with semantic dementia (SemD) frequently report tinnitus and hyperacusis but the significance and basis for these symptoms have not been elucidated. METHODS 43 patients with a diag...

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ژورنال

عنوان ژورنال: Frontiers in Neurology

سال: 2014

ISSN: 1664-2295

DOI: 10.3389/fneur.2014.00179