Behavioral profiling as a translational approach in an animal model of posttraumatic stress disorder
نویسندگان
چکیده
منابع مشابه
Toward an animal model of posttraumatic stress disorder.
Posttraumatic stress disorder (PTSD) belongs to the most frequent anxiety disorders. Despite a broad body of evidence concerning neurobiological correlates of this illness, the pathomechanisms of PTSD are still poorly understood. This illustrates the need to establish animal models of this disorder. Recently, PTSD model has become a somewhat fashionable term used in animal studies for almost ev...
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Objective: Arbutin has been shown to have antioxidant and free-radical scavenging properties. The aim of this study was to investigate the effects of arbutin administration on behavioral impairment, and oxidative and nitrosative stress in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced animal model of Parkinson’s disease (PD). Materials and Methods: PD model was developed by 4 int...
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Previous studies have demonstrated that rats subjected to single prolonged stress (SPS) exhibit posttraumatic stress disorder (PTSD)-like symptoms, such as enhanced contextual fear in response to trauma-related and trauma-unrelated events. Furthermore, we previously reported that upregulation of hippocampal glycine transporter 1 (GlyT-1) mRNA after context exposure could be the initial mechanis...
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INTRODUCTION This study examined the effect of endurance exercise on dendritic arborization in the dentate gyrus subregion in rodents exposed to a predator scent stress (PSS). METHODS Sprague-Dawley rats were randomly assigned to one of four treatment groups. In two of the groups, rats were unexposed to PSS but either remained sedentary (SED + UNEXP) or were exercised (EX + UNEXP). In the oth...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2016
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2016.01.012