Behavioural Genetics: Finding Genes that Cause Complex Trait Variation

Behavioural Genetics: Finding Genes that Cause Complex Trait Variation

Identifying genes that influence phenotypic variation is extremely difficult, especially when the allelic variants only have a small effect. A recent study has used a novel approach to identify a gene that affects the behaviour of mice.

Finding genes that underlie complex traits.

Phenotypic variation among organisms is central to evolutionary adaptations underlying natural and artificial selection, and also determines individual susceptibility to common diseases. These types of complex traits pose special challenges for genetic analysis because of gene-gene and gene-environment interactions, genetic heterogeneity, low penetrance, and limited statistical power. Emerging ...

Complex Trait Genetics Beyond Additivity

Forsberg, S. 2016. Complex Trait Genetics. Beyond Additivity. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1278. 45 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9754-5. The link between the genotype and the phenotype of an organism is immensely complex. Despite this it can, to a great extent, be captured using models that assume that gene...

Complex trait genetics in mice

Genetics: Finding Genes for Schizophrenia

New studies have substantially advanced our understanding of the genetic architecture of schizophrenia, but we are far from identifying the underlying mutations. We may require new approaches to understand the biological implications of insights into the genetics of psychiatric disease.