Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment
نویسندگان
چکیده
منابع مشابه
The Efficacy of Propofol and Midazolam in Treatment of Refractory Status Epilepticus in Children
Background: In this study, we compared the efficacy and safety of propofol and midazolam in treatment of children’s refractory status epilepticus. Methods: We recruited 32 patients with refractory status epilepticus. Of those, 16 were treated primarily with midazolam and 16 received propofol. Results: We achieved complete seizure control in 6 (38%) patients treated by midazolam, and in 10 (63%)...
متن کاملStatus epilepticus and refractory status epilepticus management.
Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically, identifies and manages any precipitant con...
متن کاملPathophysiology of Status Epilepticus
Status epilepticus is refractory to initial intravenous anticonvulsants in every third patient and at least the generalised convulsive form is commonly associated with neuronal long-term consequences. The understanding of pathophysiological mechanisms underlying development and maintenance of status epilepticus and its sequelae is therefore of uttermost importance. Spontaneous seizure terminati...
متن کاملRefractory status epilepticus.
Refractory status epilepticus (RSE) is a common problem in intensive care units and emergency departments. The important risk factor predisposing patients with SE to RSE is delay in receiving treatment. Self-sustaining SE is associated with progressive, time-dependent development of pharmacoresistance. Early termination of convulsive SE by aggressive treatment is the best way to prevent RSE. RS...
متن کاملRefractory status epilepticus
Status epilepticus is a life threatening neurological emergency. In persons with status epilepticus, if administration of a benzodiazepine and at least one antiepileptic drug has failed then management protocols for refractory status epilepticus should be put into effect. The article summarises the causes, effects, pathophysiology and treatment protocols for refractory status epilepticus.The co...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2016
ISSN: 0077-8923
DOI: 10.1111/nyas.13147