Beta‐2 adrenergic receptor: a SMART team modeling project (LB106)
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of beta2-adrenergic receptor function and regulation.
It is now clear that the beta2-adrenergic receptor continuously oscillates between various conformations in the basal state, and that agonists act to stabilize one or more conformations. It is conceivable that synthetic agonists might be engineered to preferentially confine the receptor to certain conformations deemed clinically important while having a less stabilizing effect on unwanted confo...
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beta-Adrenergic receptors (beta-ARs) are members of the superfamily of G-protein-coupled receptors that mediate the effects of catecholamines in the sympathetic nervous system. Three distinct beta-AR subtypes have been identified (beta1-AR, beta2-AR, and beta3-AR). In order to define further the role of the different beta-AR subtypes, we have used gene targeting to inactivate selectively the be...
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Olfactory receptors (ORs) comprise more than half of the large class I G protein-coupled receptor (GPCR) superfamily. Although cloned over a decade ago, little is known about their properties because wild-type ORs do not efficiently reach the cell surface following heterologous expression. Receptor-receptor interactions strongly influence surface trafficking of other GPCRs, and we examined whet...
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The signatures which appear below verify the fact that all required changes have been incorporated and that the thesis/dissertation has received iii ACKNOWLEDGMENTS It has always been my dream to discover the unknown, understand the truth beneath the phenomena, and apply what I have learned to benefit us human beings. I was born in a traditional Taiwanese family in which education is always of ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2014
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.28.1_supplement.lb106