Beyond Microarrays

Bioinformatics: Microarrays Analyses and Beyond

We have witnessed in the past years the rapid progresses in the human genome project and biotechnologies. These advances result in many complex datasets associated with indepth scientific knowledge, e.g., genome sequences of many species, microarray expression profiles of different cell lines, single nucleotide polymorphisms (SNPs) in the human genome, etc. These data together with their underl...

Reading Head : Microarrays and Beyond 1 2 Microarrays and Beyond : What Potential do 3 Current and Future Genomics Tools have for Breeders ?

Microarrays

Microarrays are revolutionizing genetics by making it possible to genotype hundreds of thousands of DNA markers and to assess the expression (RNA transcripts) of all of the genes in the genome. Microarrays are slides the size of a postage stamp that contain millions of DNA sequences to which single-stranded DNA or RNA can hybridize. This miniaturization requires little DNA or RNA and makes the ...

Microarrays and beyond: what potential do current and future genomics tools have for breeders?

One of the most exciting tools from genomics is the ability to obtain a whole-genome snapshot of gene expression. This is typically called a microarray analysis, because probes for the genes of interest, which can run into the thousands, are spotted in a very small array on a glass slide or some other substrate. The resulting array is often called a gene chip, or simply a chip, in the case of s...

An Overview Of DNA Microarrays: From Technology To Biology And Beyond

The so-called central dogma of molecular biology describes the flow of biological information: from DNA, to RNA, to protein. In molecular terms, when a biological pathway is operative, genomic DNA (eg, a gene) is transcribed into messenger RNA (mRNA; also known as the transcript), and this RNA is translated into protein (the gene product). The protein is the primary molecular machinery that car...