Bidirectional synaptic plasticity can explain bidirectional retrograde effects of emotion on memory
نویسندگان
چکیده
منابع مشابه
Bidirectional synaptic plasticity can explain bidirectional retrograde effects of emotion on memory.
Emotional events can either impair or enhance memory for immediately preceding items. The GANE model explains this bidirectional effect as a glutamate "priority" signal that modulates noradrenaline release depending on arousal state. We argue for an alternative explanation: that priority itself evokes phasic noradrenaline release. Thus, contrasting E-1 memory effects are explained by a mechanis...
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Activity-dependent synaptic delivery of GluR1-, GluR2L-, and GluR4-containing AMPA receptors (-Rs) and removal of GluR2-containing AMPA-Rs mediate synaptic potentiation and depression, respectively. The obvious puzzle is how synapses maintain the capacity for bidirectional plasticity if different AMPA-Rs are utilized for potentiation and depression. Here, we show that synaptic AMPA-R exchange i...
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ژورنال
عنوان ژورنال: Behavioral and Brain Sciences
سال: 2016
ISSN: 0140-525X,1469-1825
DOI: 10.1017/s0140525x15001958