Bilateral saccadic deficits following large and reversible inactivation of unilateral frontal eye field
نویسندگان
چکیده
منابع مشابه
Bilateral saccadic deficits following large and reversible inactivation of unilateral frontal eye 1 field
Correspondence should be addressed to: 9 10 Dr. Brian D. Corneil 11 Robarts Research Institute 12 100 Perth Drive 13 London, Ontario, Canada N6A 5K8 14 Phone: (519) 663-5777, ext 24132 15 E-mail: [email protected] 16 17 Number of figures: 14 Number of Tables: 0 18 Number of pages: 48 19 Words in abstract: 232 20 21
متن کاملBilateral saccadic deficits following large and reversible inactivation of unilateral frontal eye field.
Inactivation permits direct assessment of the functional contribution of a given brain area to behavior. Previous inactivation studies of the frontal eye field (FEF) have either used large permanent ablations or reversible pharmacological techniques that only inactivate a small volume of tissue. Here we evaluated the impact of large, yet reversible, FEF inactivation on visually guided, delayed,...
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To evaluate smooth-pursuit (SP) function in the primate frontal eye field (FEF), microinjections of muscimol, a gamma-aminobutyric acid (GABA) agonist, were used to reversibly deactivate physiologically characterized sites in FEF. SP was severely impaired by deactivation at sites in the FEF's smooth eye movement region (FEFsem) located in the fundus and posterior bank of the macaque monkey's ar...
متن کاملIntracortical microstimulation of bilateral frontal eye field.
We trained two monkeys to perform a fixation task. Intracortical microstimulation (ICMS) was applied to the monkey frontal eye field (FEF) while monkeys were fixating on one of five fixation LEDs. The ICMS was applied in two different manners. Under the single stimulation condition, ICMS was delivered to either right or left FEF. Under the paired stimulation condition, bilateral FEF were succes...
متن کاملFrontal Eye Field Inactivation Diminishes Superior Colliculus Activity, But Delayed Saccadic Accumulation Governs Reaction Time Increases.
Stochastic accumulator models provide a comprehensive framework for how neural activity could produce behavior. Neural activity within the frontal eye fields (FEFs) and intermediate layers of the superior colliculus (iSC) support such models for saccade initiation by relating variations in saccade reaction time (SRT) to variations in such parameters as baseline, rate of accumulation of activity...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2014
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00398.2013