Biocompatibility of 2D silicon nitride: interaction at the nano-bio interface

نویسندگان

چکیده

Abstract Determining potential abilities of nanostructures to induce toxicity biological molecules is still a convoluted challenge in the realm nanomedicine. Based on unprecedented achievements two-dimensional nanomaterials nearly all areas applied sciences particularly medicine, we carried out all-atom molecular dynamics simulations assess biologically important, yet unmapped issue biocompatibility 2D, hexagonal β -Si 3 N 4 nanosheet via investigating its possible cross interactions with both human serum albumin (HSA) and p53 tumor suppressor. Examining conventional MD indicators presence absence monolayer revealed that Si weakly binds these two proteins without inducing any dramatic change their secondary structures, revealing accordingly compatibility case it released as therapeutics or carriers vivo . This finding was also broadly supported by related time-dependent behaviors protein-monolayer well protein-water interaction energies.

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ژورنال

عنوان ژورنال: Materials research express

سال: 2021

ISSN: ['2053-1591']

DOI: https://doi.org/10.1088/2053-1591/ac24cc