Biological Significance of GPCR Heteromerization in the Neuro-Endocrine System
نویسندگان
چکیده
منابع مشابه
Biological Significance of GPCR Heteromerization in the Neuro-Endocrine System
Clustering of proteins in higher order complexes is a common theme in biology and profoundly influences protein function. The idea that seven-transmembrane spanning G protein-coupled receptors (GPCRs) might form dimers or higher order oligomeric complexes has been formulated more than 20 years ago. Since then, this phenomenon has been investigated with many different biochemical and biophysical...
متن کاملDevelopment of Techniques for the Demonstration of GPCR Heteromerization
receptors, the ed (56). In 200 detected hete adenosine A1 the first demo with different the agonistdopamine D2 the same year The coimm tors has the dr tion using advances were cal methods b [bioluminesce and fluorescen became possi heterodimers FRET techniq mosaic could b after its demo (35, 52). Thes investigation o ous expansi approaches in combined BR complementa Interestingly, physical reso...
متن کاملExploring a role for heteromerization in GPCR signalling specificity.
The critical involvement of GPCRs (G-protein-coupled receptors) in nearly all physiological processes, and the presence of these receptors at the interface between the extracellular and the intracellular milieu, has positioned these receptors as pivotal therapeutic targets. Although a large number of drugs targeting GPCRs are currently available, significant efforts have been directed towards u...
متن کاملthe significance of conjunction as a cohesive device in teaching writing
the research questions were as follows: 1. is there any relationship between the students concious awareness of the form and implications of the conjuncations and their improvement in using appropriate conjunctions? 2. does students knowledge of the from and the implications of the conjunctions help them to produce more coherent writings. 3. does a comparison between english conjunctions and th...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2011
ISSN: 1664-2392
DOI: 10.3389/fendo.2011.00002