Biomarker Development, Methodological Challenges

نویسندگان

چکیده

Biomarker development is a common endeavor in medical research. The purpose to find indicators of disease occurrence or prognostic markers for response. process biomarkers often starts with showing mean differences between responders and non-responders those condition versus without. However, these statistically significant differences, while necessary are not sufficient validate biomarker. Sensitivity, specificity, positive negative predictive value at least as important the relative increase performance using biomarker over usual clinical variables should be demonstrated. This paper discusses various assessments context use biomarker, need characteristics addition importance independent validation putative biomarkers. Lastly, it hoped that thoroughness considered recognition task best difficult task.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Methodological challenges for understanding cognitive development in infants.

Studies of cognitive development in human infants have relied almost entirely on descriptive data at the behavioral level - the age at which a particular ability emerges. The underlying mechanisms of cognitive development remain largely unknown, despite attempts to correlate behavioral states with brain states. We argue that research on cognitive development must focus on theories of learning, ...

متن کامل

Overcoming Methodological Challenges

Questions about the relative merits of alternative research strategies

متن کامل

A Perspective on Challenges and Issues in Biomarker Development and Drug and Biomarker Codevelopment

A workshop sponsored by the National Cancer Institute and the US Food and Drug Administration addressed past lessons learned and ongoing challenges faced in biomarker development and drug and biomarker codevelopment. Participants agreed that critical decision points in the product life cycle depend on the level of understanding of the biology of the target and its interaction with the drug, the...

متن کامل

Methodological Challenges for Collaborative Learning

Personal use of this manuscript is permitted. Permission from Elsevier must be obtained for any other commercial purpose. This article may not exactly replicate the published version, due to editorial changes and/or formatting and corrections during the final stage of publication. Interested readers are advised to consult the published version which can be found at:

متن کامل

Methodological Challenges in Online Trials

Health care and health care services are increasingly being delivered over the Internet. There is a strong argument that interventions delivered online should also be evaluated online to maximize the trial's external validity. Conducting a trial online can help reduce research costs and improve some aspects of internal validity. To date, there are relatively few trials of health interventions t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: RRNMF Neuromuscular journal

سال: 2023

ISSN: ['2692-3092']

DOI: https://doi.org/10.17161/rrnmf.v4i3.18973