Biomimetic Approaches for Bone Tissue Engineering

Biomimetic Calcium Phosphate-Polycarbonate Composite Scaffolds for Bone Tissue Engineering

Shuang S Chen and Joachim Kohn New Jersey Center for Biomaterials, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, United States. Statement of Purpose: Large bone defects resulting from trauma, tumor resection, congenital abnormalities or reconstructive surgery are challenging clinical problems that are usually treated with autografts and allografts. However, donor sit...

Biomimetic coatings for bone tissue engineering of critical-sized defects.

The repair of critical-sized bone defects is still challenging in the fields of implantology, maxillofacial surgery and orthopaedics. Current therapies such as autografts and allografts are associated with various limitations. Cytokine-based bone tissue engineering has been attracting increasing attention. Bone-inducing agents have been locally injected to stimulate the native bone-formation ac...

Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering.

The fracture of bones and large bone defects owing to various traumas or natural ageing is a typical type of tissue malfunction. Surgical treatment frequently requires implantation of a temporary or permanent prosthesis, which is still a challenge for orthopaedic surgeons, especially in the case of large bone defects. Mimicking nanotopography of natural extracellular matrix (ECM) is advantageou...

Manufacturing a Biomimetic Biorecator in Cardiac Tissue Engineering

Introduction: The direct approach of cardiac tissue engineering is to mimic the natural tissue of heart, considering the significant role of scaffolding and mechanical simulation.  Methods: To achieve this purpose, a composite Polycaprolactone (PCL)/Gelatin electrospun scaffold with a ratio of 70:30 and with the most similarities to the cardiac extracellular matrix was fabricated with aligned ...

Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering