Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review

Bisphenol A (BPA) and its substitutes bisphenol S (BPS) F (BPF) are endocrine disrupting chemicals widely used in the production of polycarbonate plastics, epoxy resins thermal papers. The aim review was to identify occupational studies using human biomonitoring (HBM) as a tool for exposure assessment characterize research gaps on topic part HBM4EU project. Hence, systematic literature search Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) methodology conducted articles published between 2000 27th March 2020 across three databases (PubMed, Scopus Web Science). Thirty HBM BPA met inclusion criteria. Regarding BPS BPF, only 4 2 publications were retrieved, respectively. Fifty-seven percent (57%) selected Asia whereas half BPF undertaken Europe. Studies plastic resin sectors infrequent Europe while Asian data showed higher when substance is employed raw material. main among cashiers available from incinerator workers. Several have been identified: (i) shortage exposure, especially BPF; (ii) different methodological designs making suitable comparisons difficult; (iii) few industrial applications bisphenols outside Asia. This highlights lack recent need harmonized approach acquire reliable data. Considering increasing replacement by it relevance evaluate these substances impact risk management measures workers possible health risk. • Review BPA, BPF. Further tools needed. Harmonized sample collection analysis required. Future work needs consider co-exposure several bisphenols. Workplace contribution overall should also be provided.