Biphasic Vasoconstriction of the Rabbit Ear Artery
نویسندگان
چکیده
منابع مشابه
Biphasic vasoconstriction of the rabbit ear artery.
Sympathetic nerve stimulation and intralummal norepinephrine infusion for more than 15 seconds produced a biphasic response in the isolated rabbit ear artery perfused with RREBS solution. This response consisted of an initial rapid constriction (phase A), which was followed by partial relaxation, and a final slowly developing constriction (phase B), which lasted for the duration of nerve stimul...
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The perfused rabbit ear artery shows a biphasic contractile response to intraluminal norepinephrine and sympathetic nerve stimulation. The peak of the first phase occurs after approximately 10 seconds of exposure to NE, and the second, after IK to 2 minutes. The magnitudes of the two responses are similar. The time course of the second phase of contraction is similar to the rate of saturation o...
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When examined by fluorescence microscopy the rabbit basilar artery contains a rich adrenergic-like plexus at the adventitiomedial junction. The fluorescence disappears upon chronic reserpinization and bilateral superior cervical ganglionectomy. Transmural stimulation of intramural nerves a results in a response which is predominantly constrictor but also contains a small, inconstant dilator com...
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The alpha-1L adrenoceptor (AR) was identified in rabbit ear artery by both functional and ligand binding studies. In functional studies using arterial rings, the contractile response to NS-49 [(R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluorometh-anesulfonanilide hydrochloride] (alpha-1A and alpha-1L AR-selective agonist) was competitively antagonized with low affinities by prazosin, RS-17053 [N-[2...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1973
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.32.1.49