BKCachannel dysfunction in neurological diseases

BKCa channel dysfunction in neurological diseases

The large conductance, Ca(2+)-activated K(+) channels (BKCa, KCa1.1) are expressed in various brain neurons where they play important roles in regulating action potential duration, firing frequency and neurotransmitter release. Membrane potential depolarization and rising levels of intracellular Ca(2+) gated BKCa channels, which in turn results in an outward K(+) flux that re/hyperpolarizes the...

orofacial manifestations of neurological diseases

چکیده ندارد.

Neural Mechanisms of Autonomic Dysfunction in Neurological Diseases

Immunological Basis of Neurological Diseases

Clinical neurology has been traditionally considered as an academic speciality in which the specialist regurgitates his/her knowledge of neurology without being able to do much for the patient. This attitude is no longer acceptable. Surge of information and discoveries in neurosciences within the last two decades translated into therapeutic interventions which is literally life saving in some o...

Ionotropic Glutamate Receptors and their Role in Neurological Diseases

Glutamate is extensively and relatively uniformly distributed in the central nervous system (CNS) and its effects mediated by two distinct groups of receptors including Ionotropic and metabotropic glutamate receptors. Concentration of glutamate in the nervous system is much higher than in other tissues. Glutamate receptors play an important role in synaptic transmission, neural plasticity and n...