Blocking hyaluronan synthesis
نویسندگان
چکیده
منابع مشابه
A blocking antibody to the hyaluronan receptor for endocytosis (HARE) inhibits hyaluronan clearance by perfused liver.
Hyaluronan (HA) and chondroitin sulfate clearance from lymph and blood is mediated by the hyaluronan receptor for endocytosis (HARE). The purification and molecular cloning (Zhou, B., Weigel, J. A., Saxena, A., and Weigel, P. H. (2002) Mol. Biol. Cell 13, 2853-2868) of this cell surface receptor were finally achieved after we developed monoclonal antibodies (mAbs) against HARE. There are actual...
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Hyaluronan is a large glycosaminoglycan consisting of alternating Nacetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) units. It is synthesized by hyaluronan synthase enzymes (HAS1,2,3). In many tissues hyaluronan is a major component of the extracellular matrix. It enhances cell proliferation, migration, and controls differentiation. High hyaluronan levels are associated with cancer progres...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2019
ISSN: 1474-1776,1474-1784
DOI: 10.1038/d41573-019-00110-y