Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas
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چکیده
منابع مشابه
Bone morphogenetic protein 7 expression associates with bone metastasis in breast carcinomas.
BACKGROUND We recently showed that bone morphogenetic protein 7 (BMP7) is overexpressed in primary breast tumors. Here we explored the clinical significance of BMP7 expression in breast cancer. MATERIALS AND METHODS This study included 483 breast cancer patients with complete clinicopathological information and up to 15 years of follow-up. Samples contained 241 lobular carcinomas, 242 ductal ...
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Bone morphogenetic protein 7 (BMP7) counteracts the physiological epithelial-to-mesenchymal transition (EMT), a process that is indicative of epithelial plasticity. Because EMT is involved in cancer, we investigated whether BMP7 plays a role in breast cancer growth and metastasis. In this study, we show that decreased BMP7 expression in primary breast cancer is significantly associated with the...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2008
ISSN: 0923-7534
DOI: 10.1093/annonc/mdm453