Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

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Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis

18 cloned T cell lines reactive with Borrelia burgdorferi proteins, all CD3+4+8-TCR-alpha/beta+ and restricted by HLA class II proteins, were isolated from four patients with chronic Lyme arthritis. Analysis of these T cell clones indicated that the T cell response to the Lyme disease spirochete is not oligoclonally restricted; yet all produced the same pattern of lymphokines, resembling that o...

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Borrelia burgdorferi-specific T lymphocytes induce severe destructive Lyme arthritis.

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Selection of a human T helper type 1-like T cell subset by mycobacteria

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The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis

The host response to Borrelia burgdorferi is likely to play a role in the pathogenesis of Lyme arthritis. Whereas most patients with Lyme arthritis can be cured with antibiotic therapy, approximately 10% of the patients have persistent arthritis for months or even several years after antibiotic treatment. In this study, we tested the hypothesis that the T cell response to one or more antigens o...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1991

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.174.3.593