Both angiotensinogen M235T and α-adducin G460W polymorphisms are associated with hypertension in the Japanese population
نویسندگان
چکیده
منابع مشابه
Angiotensinogen-M235T genotype and post-transplant hypertension.
BACKGROUND The angiotensinogen gene has been linked to the development of essential hypertension, and a M235T variant of this gene, associated with increased plasma levels of angiotensinogen, is more common in hypertensives than in normotensive controls in various populations. The present study was conducted to examine whether the M235T variant of the angiotensinogen gene may be a risk factor f...
متن کاملGene Polymorphisms of Adducin GLY460TRP, ACE I/D, and AGT M235T in Pediatric Hypertension Patients
BACKGROUND Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension. MATERIAL AND METHODS Included in the study wer...
متن کاملMeta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?
Angiotensinogen (AGT) gene polymorphisms have been linked to increased risk of hypertension, but the data remain controversial. In this study we review the most commonly investigated polymorphisms at the AGT locus (other than M235T) and provide summary estimates regarding their association with essential hypertension, while addressing heterogeneity, as well as publication biases. Data on 26 818...
متن کاملAre polymorphisms in MTRR A66G and MTHFR C677T genes associated with congenital heart diseases in Iranian population?
Background: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism. The relationship between genetic polymorphisms and congenital heart defects (CHDs) is inconsistent. Our aim was to investigate the association between two well-known polymorphisms of MTHFR and MTRR genes, C677T and A66G, respectively,...
متن کاملHypertension Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population
Background—Two consortium-based genome-wide association studies have recently identified robust and significant associations of common variants with systolic and diastolic blood pressures in populations of European descent, warranting further investigation in populations of non-European descent. Methods and Results—We examined the associations at 27 loci reported by the genome-wide association ...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 2007
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1002135