Brain Signal Variability Differentially Affects Cognitive Flexibility and Cognitive Stability

Brain Signal Variability Differentially Affects Cognitive Flexibility and Cognitive Stability.

UNLABELLED Recent research yielded the intriguing conclusion that, in healthy adults, higher levels of variability in neuronal processes are beneficial for cognitive functioning. Beneficial effects of variability in neuronal processing can also be inferred from neurocomputational theories of working memory, albeit this holds only for tasks requiring cognitive flexibility. However, cognitive sta...

Stochastic Dynamics Underlying Cognitive Stability and Flexibility

Cognitive stability and flexibility are core functions in the successful pursuit of behavioral goals. While there is evidence for a common frontoparietal network underlying both functions and for a key role of dopamine in the modulation of flexible versus stable behavior, the exact neurocomputational mechanisms underlying those executive functions and their adaptation to environmental demands a...

A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning

Whether the opioid system plays a role in the ability to flexibly adapt behavior is still unclear. We used fMRI to investigate the effect of a nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin (PDYN) gene on cerebral activation during a reversal learning task in which participants had to flexibly adapt stimulus-response associations. Past studies suggested that a...

Cognitive Flexibility

Cognitive Flexibility + Social Constructivism

The Internet Web Site on Virtual Clinical Applications and Disease Management is a hypermedia, case-based open learning environment that was designed to promote cognitive flexibility in college students at The University of Georgia College of Pharmacy. With a key objective of pharmacy education being patient problem-solving skills, this environment exposes students to a variety of resources on ...