Brain tissue echogenicity—implications for substantia nigra studies in parkinsonian patients
نویسندگان
چکیده
منابع مشابه
Controversies about iron in parkinsonian and control substantia nigra.
According to the oxidative stress theory iron may play an important role in the pathogenesis of neurodegenerative diseases, as e.g. Parkinson's disease (PD). This review presents the results of studies, obtained by various methods, of iron in substantia nigra (SN)--a cerebral structure which degenerates in PD--and shows controversies concerning the amount of iron, its redox state, and the iron ...
متن کاملPotential sources of increased iron in the substantia nigra of parkinsonian patients.
Histopathological, biochemical and in vivo brain imaging techniques, such as magnetic resonance imaging and transcranial sonography, revealed a consistent increase of substantia nigra (SN) iron in Parkinson's disease (PD). Increased iron deposits in the SN may have genetic and non-genetic causes. There are several rare movement disorders associated with neurodegeneration, and genetic abnormalit...
متن کاملConstructing a new nigrostriatal pathway in the Parkinsonian model with bridged neural transplantation in substantia nigra.
The physical repair and restoration of a completely damaged pathway in the brain has not been achieved previously. In a previous study, using excitatory amino acid bridging and fetal neural transplantation, we demonstrated that a bridged mesencephalic transplant in the substantia nigra generated an artificial nerve pathway that reinnervated the striatum of 6-hydroxydopamine (6-OHDA)-lesioned ra...
متن کاملPersistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques.
Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details...
متن کاملIron in parkinsonian and control substantia nigra--a Mössbauer spectroscopy study.
We used Mössbauer spectroscopy to study the iron content, the redox state, and the binding site of iron in substantia nigra (SN) from parkinsonian (PD) and control brains. Measurements performed on fresh-frozen, formalin-fixed, and lyophilized samples demonstrated the presence of ferric (Fe3+) iron only, both in PD and control SN. Ferrous iron, if present at all, may represent at most 5% of the...
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ژورنال
عنوان ژورنال: Journal of Neural Transmission
سال: 2011
ISSN: 0300-9564,1435-1463
DOI: 10.1007/s00702-011-0707-5