BRCA1 Regulates Acetylation and Ubiquitination of Estrogen Receptor-α
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چکیده
منابع مشابه
Phosphorylation of Estrogen Receptor Blocks Its Acetylation and Regulates Estrogen Sensitivity
Estrogen receptor (ER) is mutated (lysine 303 to arginine, K303R) in approximately one third of premalignant breast hyperplasias, which renders breast cancer cells expressing the mutant receptor hypersensitive for proliferation in response to low doses of estrogen. It is known that ER is posttranslationally modified by protein acetylation and phosphorylation by a number of secondary messenger s...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2010
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2009-0218