BRCA2: a universal recombinase regulator

Cre recombinase: the universal reagent for genome tailoring.

In September 1998 the workshop for “Conditional Genome Alterations” in Cold Spring Harbor had a simple but important take-home message: “Cre works” (Rossant and McMahon, 1999). After several years of careful investigations, geneticists are now certain that the Cre recombinase of the P1 bacteriophage efficiently catalyzes recombination between two of its consensus 34 base pair DNA recognition si...

Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1.

Germline mutations in BRCA2 predispose to hereditary breast cancers. BRCA2 protein regulates recombinational repair by interaction with RAD51 via a series of degenerate BRC repeat motifs encoded by exon 11 (BRCA2(996-2113)), and an unrelated C-terminal domain (BRCA2(3265-3330)). BRCA2 is also required for meiotic recombination. Here, we show that human BRCA2 binds the meiosis-specific recombina...

Realization of the Universal Microcontroller Power Regulator

1 Vladan V. Vu kovi , The Faculty of Electronic Engineering, Serbia (phone: 381-018-529523; e-mail: [email protected]). Abstract The paper presents basic construction principles of the universal electronic power regulator using the microcontroller Microchip PIC16F84 coupled with optoelectronic component and standard triac BT 139/800. The device runs using the phase control of the network alter...

Mani and shapur a universal faith for e universal kingdom

DYNAMIC SIMULATION OF A HIGH PRESSURE REGULATOR

In this paper, the dynamic simulation for a high pressure regulator is performed to obtain the regulator behavior. To analyze the regulator performance, the equation of motion for inner parts, the continuity equation for diverse chambers and the equation for mass flow rate were derived. Because of nonlinearity and coupling, these equations are solved using numerical methods and the results are ...