Building new roads to stronger immunity

President's Page: New ACC/AHA prevention guidelines: building a bridge to even stronger guideline collaborations.

T his past month, the American College of Cardiology (ACC) and the American Heart Association (AHA), in collaboration with the National Heart, Lung, and Blood Institute (NHLBI) and other specialty societies, released 4 long-awaited guidelines focused on the assessment of cardio-vascular risk, lifestyle modifications to reduce cardiovascular risk, and management of elevated blood cholesterol and...

New roads leading to Ca2+ sensitization.

Gprotein–coupled receptors (GPCRs) activated by a wide variety of agonists can switch on myosin light chain phosphorylation and force in smooth muscle. The extent of myosin light chain phosphorylation reflects activity of both the Ca /calmodulin–dependent myosin light chain kinase (MLCK) and the myosin light chain phosphatase. Thus, at constant Ca and MLCK activity, processes that inhibit myosi...

Building a Stronger, More Equitable Rhode Island.

From its beginning, HIV has primarily affected marginalized populations, such as injection drug users, gay, bisexual and other men who have sex with men (GBMSM), and minority racial and ethnic groups. HIV is a disease that, from the start, has been strongly influenced by issues related to social justice and health equity due to its intersection with behaviors among at-risk populations. While so...

The New Silk Roads

Iran’s security is affected by a broad region that includes the Caspian Basin, Central Asia, Afghanistan, the Persian Gulf states, Pakistan, Turkey, and the Middle East. However, an increased focus on the countries of the Economic Cooperation Organization (ECO), as well as Iraq, on the one hand, and with members of the Gulf Cooperation Council (GCC) (including Yemen) on the other, provides a na...

Priority Setting on the Path to UHC: Time for Stronger Institutions and Stronger Health Systems: Response to Recent Commentaries