Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function
نویسندگان
چکیده
منابع مشابه
Targeted proteolysis sustains calcineurin activation.
BACKGROUND Calcineurin (CnA) is important in the regulation of myocardial hypertrophy. We demonstrated that targeted proteolysis of the CnA autoinhibitory domain under pathological myocardial workload leads to increased CnA activity in human myocardium. Here, we investigated the proteolytic mechanism leading to activation of CnA. METHODS AND RESULTS In patients with diseased myocardium, we fo...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2016
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2016.05.007