Calcium-activated muscle from hypertrophied rabbit hearts. Mechanical and correlated biochemical changes.
نویسندگان
چکیده
منابع مشابه
Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts.
Cardiac hypertrophy, induced by pressure overload, leads to a depression in the rate of force development, velocity of shortening, tension-dependent heat generation, and myosin ATPase activity, whereas cardiac hypertrophy, induced by thyroxine administration, leads to an increase in these parameters. These changes have been attributed, in part, to structural changes in myosin. In this study, we...
متن کاملContractile reserve and intracellular calcium regulation in mouse myocytes from normal and hypertrophied failing hearts.
Mouse myocyte contractility and the changes induced by pressure overload are not fully understood. We studied contractile reserve in isolated left ventricular myocytes from mice with ascending aortic stenosis (AS) during compensatory hypertrophy (4-week AS) and the later stage of early failure (7-week AS) and from control mice. Myocyte contraction and [Ca(2+)](i) transients with fluo-3 were mea...
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To evaluate the smooth muscle mechanical and biochemical changes associated with persistent pulmonary hypertension syndrome of the newborn, we studied 31 fetal sheep in which the ductus arteriosus was ligated at 125 days of gestation. Sixty-one noninstrumented and six sham-operated fetuses served as controls. All animals were delivered by cesarean section at 137-140 days of gestation, and the e...
متن کاملThe Mechanical Characteristics of Hypertrophied Rabbit Cardiac Muscle in the Absence of Congestive Heart Failure
Right ventricular papillary muscles from normal rabbits and rabbits with sustained pulmonary artery constriction (67% decrease in external diameter) were studied at several resting muscle lengths and at an early instant in the isometric twitch. Instantaneous force-velocity data were obtained at 3038% of time to peak tension (TPT) and at 96%, 98%, and 100% of the resting muscle length at which a...
متن کاملInotropic response of stunned hypertrophied myocardium: responsiveness of hypertrophied and normal postischemic isolated rat hearts to calcium and dopamine stimulation.
OBJECTIVE Severely hypertrophied myocardium was described to have a reduced tolerance towards ischemia. For non-hypertrophied hearts inconclusive findings on the Ca(2+)-responsiveness are reported. Information sensitivity to reversible ischemia and on postischemic Ca(2+)-responsiveness of hearts with clinically common moderate hypertrophy is lacking. Thus, the responsiveness of hypertrophied an...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1979
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.44.2.279