CALCIUM ION ACCUMULATION AND VOLUME CHANGES OF ISOLATED LIVER MITOCHONDRIA. REVERSAL OF CALCIUM ION-INDUCED SWELLING
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چکیده
منابع مشابه
The sodium ion/calcium ion cycle of cardiac mitochondria.
A number of advances have been made recently in our knowledge of the mechanisms of mitochondrial Ca2+ transport, and these offer new perspectives to the problem of why mitochondria transport Cal+. Progress with cardiac mitochondria has been favoured by the resolution of the overall flux of Caz+ across the inner membrane into two distinct components, which represent catalysis by two separate car...
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چکیده ندارد.
15 صفحه اولIon-induced Ultrastructural Transformations in Isolated Mitochondria
The energized uptake of low levels of Ca(2+) in the presence and absence of phosphate by isolated rat liver mitochondria, and the perturbation effected by this activity on ultrastructural and metabolic parameters of mitochondria have been investigated. In the presence of phosphate, low levels of Ca(2+) are taken up by mitochondria and result in various degrees of ultrastructural expansion of th...
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When toxic doses of CC& were given to rats, there ensued marked accumulations of Ca++ and inorganic orthophosphate by whole liver commencing 6 hours after treatment. When these livers were homogenized in 0.25 M sucrose, the Ca++ and Pi concentrations of the mitochondria subsequently harvested were elevated several fold, reflecting the higher levels of these ions in the whole tissue. The Kf conc...
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The swelling of isolated bovine heart and rat liver mitochondria has been compared in various suspending media in the absence of a source of metabolic energy. It is concluded that mitochondria will swell under these conditions in the presence of a permeant anion and a permeant cation, provided that the internal pH is not restrictive. Mitochondria show a high selectivity for cation penetration i...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1965
ISSN: 0006-2936
DOI: 10.1042/bj0950387