Caloric restriction and intermittent fasting: Two potential diets for successful brain aging

Caloric Restriction, Fasting and Nicotinamide Riboside | Anti-Aging | Articles | Magazine

[Caloric restriction and anti-aging].

エレガンス線虫の寿命は約 3 週間で寿命の遺伝学的解 析に適している.研究室で実験に使っている野生型線虫 (N2)は,20°C で飼育すると,最大寿命が 21 日前後な ので,10 日目には中年特有の表現系を示すことが知ら れている.実際,顕微鏡で観察すると,10 日目には消 化管の周りの脂肪組織が急に黒ずんで目立つようにな る.この症状は脂肪細胞にトリグリセライドの蓄積が増 加するためで,ヒトにおける中年太りの内臓脂肪の蓄積 によく似た症状である. 代表的な長寿線虫,daf-2 変異体は最も遺伝解析が進 んでいる変異体である.daf-2 線虫は耐性幼虫(dauer) になりやすいことから daf(dauer formation,耐性幼虫 化)シリーズの名前が付いている.しかし,運動やリズ ムは正常で,一定温度(高温)で飼育する限り,耐性幼 虫化せずに,寿命は 1.5 倍~2 倍に延...

Dietary restriction with and without caloric restriction for healthy aging

Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20-40% reduction of food consumption relative to normal intake, is a severe intervention that re...

Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems.

Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR) extend lifespan and increase resistance to age-related diseases in rodents and monkeys and improve the health of overweight humans. Both IF and CR enhance cardiovascular and brain functions and improve several risk factors for coronary artery disease and stroke including a reduction in blood pressure and increased in...

The glucocorticoid paradox of caloric restriction in slowing brain aging.

Glucocorticoids have a bimodal effect on cognition, hippocampal pyramidal neurons and long-term potentiation (LTP). Transient increases in glucocorticoids improve performance at spatial memory tasks and facilitate synaptic efficacy, depending on the context. On the other hand, long-term elevations of glucocorticoids are associated with decreased cognitive performance, attenuated synaptic effica...