Can Enhancing Neuronal Activity Improve Myelin Repair in Multiple Sclerosis?
نویسندگان
چکیده
منابع مشابه
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker
Objective: Multiple sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As myelin basic protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP in serum, stimulated, and unstimulated saliva as a suitable biomarker for detecting MS. Methods: A case-control study was performed in 29 health...
متن کاملNerve , Myelin , and Multiple Sclerosis
Those who investigate the nervous system may do so at a variety of different levels. The student of behavior may spend much time in the observation of behaving animals. The neurophysiologist who is interested in the mechanisms underlying our senses, such as hearing or vision, concentrates on those areas of the brain that are specialized for these particular functions . In this account I would l...
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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by an inappropriate inflammatory reaction resulting in widespread myelin injury along white matter tracts. Neurological impairment as a result of the disease can be attributed to immune-mediated injury to myelin, axons and mitochondria, but the molecular mechanisms underlying the neuropathy remain...
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The presence of demyelinated plaques in the central nervous system is the hallmark of multiple sclerosis (MS). Some plaques remyelinate but others do not, leaving permanent damage. The reasons for this failure of repair are many, but one possible reason is the lack of migration of oligodendrocyte precursor cells to the lesion. The guidance molecules Semaphorin 3A and 3F, already known to direct...
متن کامل[Neuronal dysfunction in multiple sclerosis].
The precise mechanisms of cortical damage in multiple sclerosis (MS) remain unknown. Microglia, the resident immune cells in the central nervous system (CNS), are involved in the chronic neuroinflammation in MS cortical lesions. Microglia produce various inflammatory cytokines such as IFN-γ and IL-β, reactive oxygen species, and glutamate. IL-β secretion is induced by NLRP3. ROS is induced by G...
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ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2021
ISSN: 1662-5102
DOI: 10.3389/fncel.2021.645240