Can hepatitis C virus infection and interferon-alpha undo the HLA-DRB1*0402/DQB1*0302 protection against rheumatoid arthritis?
نویسندگان
چکیده
منابع مشابه
Role of HLA-B7, B8, B27, and B51 in Protection against Hepatitis B Virus Infection
Background: It has been arguedthat unprecedented degree of human leukocyte antigen (HLA) loci polymorphism within a population is requiredto avoid the devastating effects of infectious diseases. The present study was conducted to determine the associations between some of HLA classI genes and the outcome of hepatitis B virus (HBV) infection. Methods: Using sequential sampling method, 64 individ...
متن کاملProtection against rheumatoid arthritis by HLA: nature and nurture.
Rheumatoid arthritis (RA) is a complex genetic disorder in which the HLA region contributes most to the genetic risk. HLA-DRB1 molecules containing the amino acid sequence QKRAA/QRRAA/RRRAA (ie, HLA-DRB1*0101, *0102, *0401, *0404, *0405, *0408, *0410, *1001 and *1402) at position 70-74 in the third hypervariable region of the DRB1 chain are associated with susceptibility to RA. HLA-DRB1 molecul...
متن کاملrole of hla-b7, b8, b27, and b51 in protection against hepatitis b virus infection
background: it has been arguedthat unprecedented degree of human leukocyte antigen (hla) loci polymorphism within a population is requiredto avoid the devastating effects of infectious diseases. the present study was conducted to determine the associations between some of hla classi genes and the outcome of hepatitis b virus (hbv) infection. methods: using sequential sampling method, 64 indiv...
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Chronic hepatitis C virus (HCV) infections can be cured only in a fraction of patients treated with alpha interferon (IFN-alpha) and ribavirin combination therapy. The mechanism of the IFN-alpha response against HCV is not understood, but evidence for a role for viral nonstructural protein 5A (NS5A) in IFN resistance has been provided. To elucidate the mechanism by which NS5A and possibly other...
متن کاملThe Absence of Hepatitis C Virus Infection Among Patients with Hepatitis B virus in Mashhad, Iran
Background and Aims: Many studies have provided evidence for the role of hepatitis B and C viruses in the development of liver cancer. Although the routine treatment is available for both conditions, no definite guideline is available to treat patients dually infected with HBV and HCV. This study was performed to determine the frequency of HBV/HCV-coinfection in Mashhad, North-East of Iran. Mat...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2003
ISSN: 1460-2172
DOI: 10.1093/rheumatology/keg055