Cancer Cell-Specific Autophagy Activation Using Phosphorus-Based Nanoplatform as Anabolism Activator

Autophagy suppresses tumorigenesis by restoring a favorable energy balance. Activation of autophagic pathways has therefore sparked great interest as target for cancer therapy. However, the targets available autophagy activators are nonexclusively involved in cells, thus causing cytotoxicity noncancerous tissues. Stimulation anabolism and ensuing decreased levels cells central to tumor-selective induction. Herein, we present black phosphorus quantum dots (BPQDs) with red blood cell membranes (RBCMs) cloaking (BPQDs@RBCMs) tumor tumor-specific activation. The selective degradation BPQDs@RBCMs releasing phosphate microenvironment initiates falling levels. In vivo assessments confirm that treatment effectively reduces overall burden alters metabolite profiles tumor. Overall, this study underlines potential utility induction therapeutics.