Carcinogenic oestrogens induce respiration deficiency mutation in yeast
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Carcinogenic oestrogens induce respiration deficiency mutation in yeast.
In addition to hormonal activity, genetic damage has been proposed as an important factor in oestrogen-mediated carcinogenesis. However, as short-term tests for oestrogens usually fail to show DNA mutations, lesions other than classic nuclear DNA mutation have to be considered. Oestrogen-induced mitochondrial damage was studied in the yeast Saccharomyces cerevisiae. Stilbene-type, but not stero...
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essentially unchanged. The dehydrase activity, however, declined until none was detectable. (This decline commenced approximately 1 hr after maximal growth was attained.) At this latter point, the cells were viable when placed in minimal medium, but there was a 2-hr "lag" period before growth commenced. It is tempting to interpret this decline as an expression of enzyme repression, but the pres...
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In bovine oviduct cells 17beta-oestradiol can induce the synthesis of leukaemia inhibitory factor (LIF), a glycoprotein essential for embryo implantation. Therefore substances which are structurally similar to 17beta-oestradiol and possess oestrogenic activity may also modulate LIF synthesis and influence the reproductive process. We used primary cultures of bovine and human oviduct cells (epit...
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DNA polymerases must accurately replicate DNA to maintain genome integrity. Carcinogenic adducts, such as 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF), covalently bind DNA bases and promote mutagenesis near the adduct site. The mechanism by which carcinogenic adducts inhibit DNA synthesis and cause mutagenesis remains unclear. Here, we measure interactions between a DNA polymerase an...
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Adams, D. H. (1950). Brit. J. Cancer, 4, 183. Adams, D. H. (1951 a). Brit. J. Cancer, 5, 115. Adams, D. H. (1951 b). Brit. J. Cancer, 5, 409. Adams, D. H. (1952). Biochem. J. 50, 486. Adams, D. H. (1953). Biochem. J. 54; 328. Adams, D. H. (1955). Biochem. J. 60, 568. Buchanan, J. M., Hastings, A. B. & Nesbett, F. N. (1949). J. biol. Chem. 180, 435. Greenfield, R. E. & Meister, A. (1951). J. nat...
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ژورنال
عنوان ژورنال: Toxicology in Vitro
سال: 1991
ISSN: 0887-2333
DOI: 10.1016/0887-2333(91)90078-r