Case of BRAF mutant Erdheim-Chester disease presenting with multisystem involvement: A case report

Objective: Erdheim-Chester disease is a rare form of non-Langerhans cell histiocytosis unknown etiology. It multisystemic that can involve bones, skin, brain, retroperitoneum, cardiovascular system, endocrine and lungs. Diagnosis made by clinical findings, imaging results, histopathological examination. BRAFV600E (B-rapidly accelerated fibrosarcoma gene) mutation found in more than half the cases. When not considered differential diagnosis, it possible to diagnose treat. In this case report, an with symptomatic, multisystem involvement, mutation, initiated vemurafenib treatment presented light literature data.