Case report: Enteral nutritional supplement as a likely cause of false-positive galactomannan testing

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Case report: Enteral nutritional supplement as a likely cause of false-positive galactomannan testing☆

The detection of galactomannan (GM) in the serum of in immunocompromised patients is widely used for the early diagnosis of invasive aspergillosis. We report a case of a false-positive GM test presumably caused by the enteral nutritional supplement given to a non-neutropenic patient with intestinal graft-versus-host disease after a hematopoietic stem cell transplant. Clinicians should be alert ...

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Introduction. Diagnosis of invasive aspergillosis is challenging and the gold standard for definite diagnosis remains histopathological tissue examination. However, invasive procedures such as lung biopsy are often not feasible in critically ill patients. The detection of fungal cell wall components like Aspergillus galactomannan in broncho-alveolar lavage remains a key component of the diagnos...

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The detection of galactomannan (GM) in the serum of immunocompromised patients is widely used for the early diagnosis of invasive aspergillosis (6). The test may also be useful when applied to bronchoalveolar lavage (BAL) fluid specimens for clinical diagnosis (5), though not FDA approved for this use. One important limiting factor for GM testing is the potential for false-positive results. Mos...

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ژورنال

عنوان ژورنال: Medical Mycology Case Reports

سال: 2014

ISSN: 2211-7539

DOI: 10.1016/j.mmcr.2013.11.004