CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice
نویسندگان
چکیده
منابع مشابه
Optimization of the Time Window of Interest in Ovariectomized Imprinting Control Region Mice for Antiosteoporosis Research
This study was performed to determine the optimal window of time during which the properties of osteoporosis are obvious and to explore the best region of interest for microstructural evaluation in antiosteoporosis research in an ovariectomized mouse model by examining changes in micro-computed tomography parameters and serum indices. Ovariectomized mice and sham-operated mice were randomly div...
متن کاملEfects of hormone replacement and tamoxifen on depression in ovariectomized rats.
OBJECTIVES To determine the effects of tamoxifen and hormone replacement therapy in order to assess their role in depressive behavior: MATERIAL AND METHODS Different protocols of hormone replacement therapies were administered to surgically ovariectomized rats. Intact rats were used for tamoxifen experiments. Properly assigned control groups were used and cognitive processes were studied on a...
متن کاملTopical KGF treatment as a therapeutic strategy for vaginal atrophy in a model of ovariectomized mice
One of the most frequent complaints for post-menopausal women is vaginal atrophy, because of reduction in circulating oestrogens. Treatments based on local oestrogen administration have been questioned as topic oestrogens can reach the bloodstream, thus leading to consider their safety as controversial, especially for patients with a history of breast or endometrial cancers. Recently, growth fa...
متن کاملIs There A Safe, Therapeutic Window for Thyroid Hormone Therapy in Heart Failure?
Cardiovascular researchers are searching for new heart failure (HF) drugs that improve LV systolic/diastolic function and coronary blood flow, while inhibiting cardiac fibrosis, inflammation, re-expression of fetal genes, atherosclerosis, and arrhythmias. Indeed, a drug that safely accomplished all of the above would be front page news. Surprisingly, we have had such a drug in our arsenal for a...
متن کاملGene replacement rescues severe muscle pathology and prolongs survival in myotubularin-deficient mice and dogs.
Department of Rehabilitation Medicine, Institute for Stem Cell and Regenerative Medicine, School of Medicine, University of Washington, Seattle, Washington 98109, USA; The Manton Center for Orphan Disease Research, Division of Genetics and Genomics, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; Généthon, INSERM UMR 951, Evry, France Correspondence to: Martin K....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2019
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci123689