CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes
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چکیده
منابع مشابه
Imaging the Single Cell Dynamics of CD4+ T Cell Activation by Dendritic Cells in Lymph Nodes
The adaptive immune response is initiated in secondary lymphoid organs by contact between antigen-bearing dendritic cells (DCs) and antigen-specific CD4+ T cells. However, there is scant information regarding the single cell dynamics of this process in vivo. Using two-photon microscopy, we imaged the real-time behavior of naive CD4+ T cells and in vivo-labeled DCs in lymph nodes during a robust...
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The CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) play an important role in the control of peripheral tolerance by directly inhibiting conventional T cell proliferative and effector functions. However, the mechanisms by which Treg regulate the homeostasis of lymph nodes remain unclear. In this study, we show in a mouse model that Treg control two major checkpoints dictated by the interaction ...
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membrane rafts containing kinases and adapters to the Immune responses are initiated in the T cell areas of synapse and amplifies up to 100-fold the signaling prosecondary lymphoid organs, where naı̈ve T lymphocytes cess initiated by the TCRs. Thus, in the absence of encounter dendritic cells (DCs) that present antigens costimulation, naive T cells can be activated only by taken up in peripheral...
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Background: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. Objective: To investigate the percentages of CD8+ lymphocytes and their subsets in...
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Dendritic cells are potent antigen-presenting cells endowed with the unique ability to prime T-cell responses. To present foreign antigens to na ive T cells, dendritic cells must migrate from inflamed or injured peripheral tissues to the closest draining lymph nodes through afferent lymphatic vessels. In addition, conventional dendritic cells, plasmacytoid dendritic cells and monocytes enter ly...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2019
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20170277