CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage
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چکیده
منابع مشابه
Articular cartilage and changes in Arthritis: Collagen of articular cartilage
The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component in mammals, but collagens III, VI, IX, X, XI, XII and XIV all contribute to the mature matrix. In developing cartilage, the core fibrillar network is a cross-linked copolymer of collagens II, IX and XI. The functions of collagens I...
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(ii) The Upper Middle Zone.-This contains rounded cells with branching irregular processes, often arranged in pairs. In addition to cytomembranes and mitochondria, many cells exhibit pinocytotic vesicles and large Golgi vacuoles, some of which open at the cell surface. The matrix immediately around each cell or between pairs contains fine fibres; the interfibrillar matrix between pairs often sh...
متن کاملArticular cartilage changes in chondromalacia patellae.
Full thickness samples of articular cartilage were removed from areas of chondromalacia on the medial and "odd" facets of the patellae of 21 adults and examined by histology, autoradiography and electron microscopy. Surface fibrillation, loss of superficial matrix staining and reduced 35SO4 labelling was seen, with little change in the deep zone. Ten cases showed "fibrous metaplasia" of the sup...
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CONTEXT Articular cartilage has a unique functional architecture capable of providing a lifetime of pain-free joint motion. This tissue, however, undergoes substantial age-related physiologic, mechanical, biochemical, and functional changes that reduce its ability to overcome the effects of mechanical stress and injury. Many factors affect joint function in the maturing athlete-from chondrocyte...
متن کاملChanges in permeability of articular cartilage in experimental lathyrism.
Articular cartilage does not contain blood vessels, the nutrition of chrondrocytes being derived mainly by diffusion of synovial fluid (Stockwell and Barnett, 1964; Ekholm, 1951). It has been demonstrated that the permeability of articular cartilage diminishes with ageing (Stockwell and Barnett, 1964; Tsaltsas and Kyriazis, 1967). This change has been attributed not only to the physical changes...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21207556