CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function
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چکیده
منابع مشابه
Multiple treg suppressive modules and their adaptability
Foxp3(+) regulatory T cells (Tregs) are a constitutively immunosuppressive cell type critical for the control of autoimmunity and inflammatory pathology. A range of mechanisms of Treg suppression have been identified and it has not always been clear how these different mechanisms interact in order to properly suppress autoimmunity and excessive inflammation. In recent years it has become clear ...
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Regulatory T cells (Tregs) are a subset of CD4(+) T cells that maintain immune tolerance in part by their ability to inhibit the proliferation of conventional CD4(+) T cells (Tconvs). The role of the TCR and the downstream signaling pathways required for this suppressive function of Tregs are not fully understood. To yield insight into how TCR-mediated signals influence Treg suppressive functio...
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ژورنال
عنوان ژورنال: Immunology
سال: 2021
ISSN: 0019-2805,1365-2567
DOI: 10.1111/imm.13337