CD9 predicts ETV6-RUNX1 in childhood B-cell precursor acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.
The t(12;21) translocation that generates the ETV6-RUNX1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is exclusively associated with B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The translocation arises in utero and is necessary but insufficient for the development of leukemia. Single-nucleotide polymorphism array analysis of ETV6-RUNX...
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JAK2 abnormalities may serve as target for precision medicines in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In the current study we performed a screening for JAK2 mutations and translocations, analyzed the clinical outcome and studied the efficacy of two JAK inhibitors in primary BCP-ALL cells. Importantly, we identify a number of limitations of JAK inhibitor therapy. J...
متن کاملUnique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia
Overwhelming evidence indicates that long non-coding RNAs have essential roles in tumorigenesis. Nevertheless, their role in the molecular pathogenesis of pediatric B-cell precursor acute lymphoblastic leukemia has not been extensively explored. Here, we conducted a comprehensive analysis of the long non-coding RNA transcriptome in ETV6/RUNX1-positive BCP-ALL, one of the most frequent subtypes ...
متن کاملLYMPHOID NEOPLASIA Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in mice
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom; 2Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Cambridge, United Kingdom; 3The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom; 4The Institute of Cancer Research, Section of Haemato-Oncology, Surrey, United Kingdom; and 5St Jude Children’s Research Hospital, Mem...
متن کاملClonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia.
B-cell precursor childhood acute lymphoblastic leukemia with ETV6-RUNX1 (TEL-AML1) fusion has an overall good prognosis, but relapses occur, usually after cessation of treatment and occasionally many years later. We have investigated the clonal origins of relapse by comparing the profiles of genomewide copy number alterations at presentation in 21 patients with those in matched relapse (12-119 ...
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ژورنال
عنوان ژورنال: Hematology, Transfusion and Cell Therapy
سال: 2019
ISSN: 2531-1379
DOI: 10.1016/j.htct.2018.11.007