CEA and CA 15-3 Serum Level in Metastatic Breast Cancer and its Correlation with Distant Metastasis

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Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer.

The objective of this study was to investigate the association of serum cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) levels with clinicopathological parameters in patients diagnosed with metastatic breast cancer (MBC). We retrospectively evaluated the medical records of 284 patients diagnosed with MBC between January, 2007 and December, 2012 who fulfilled the specified crite...

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Importance of CEA and CA 15-3 during disease progression in metastatic breast cancer patients.

UNLABELLED The aim of this study analysis was to determine the correlation between elevation of CEA and/or CA 15-3 and disease progression of metastatic breast cancer. MATERIALS AND METHODS We investigated 119 breast cancer patients who had metachronous metastases. We evaluated levels of CEA and CA 15-3 at the time of first recurrence and at every further disease progression (PD). RESULTS I...

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Relationship between preoperative serum CA 15-3 and CEA levels and clinicopathological parameters in breast cancer.

BACKGROUND CEA and CA 15.3 serum tumor markers are currently used in clinical practice for monitoring therapy. The aim of this study was to evaluate serum level of these markers among healthy females and invasive breast carcinoma (IBC) patients and to determine any relationships with clinicopathological factors. MATERIALS AND METHODS 60 Iranian females were enrolled in this study, 30 healthy ...

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Sensitivity and Specificity of CA 15-3 in Detection of Breast Cancer Recurrence

Background: The value of CA15-3(cancer antigen 15-3) marker in early detection of breast cancer recurrence has been studied in several prospective trials. But the results of these studies are different. This may be due to variable cutoff points used for analysis, different intervals between CA15-3 measurements and the differences between patients population. This study was done to examine the p...

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Relationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancer.

BACKGROUND Serum HER-2/neu antigen concentrations have been reported to correlate with increased tumor volume in patients with breast cancer. We measured serum CA 15-3, a surrogate marker of disease burden, and correlated serum CA 15-3 with serum HER-2/neu and analyzed the association of both markers with clinical outcomes. METHODS Pretreatment serum samples from 566 patients were retrospecti...

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ژورنال

عنوان ژورنال: Biomedical and Pharmacology Journal

سال: 2015

ISSN: 0974-6242

DOI: 10.13005/bpj/775