Cell cycle, checkpoints and cancer
نویسندگان
چکیده
منابع مشابه
Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer.
It has been reported that disruption of the circadian clock may lead to increased risk of breast cancer in humans and to a high rate or ionizing radiation-induced tumors and mortality in mice. Cryptochrome 1 and cryptochrome 2 proteins are core components of the mammalian circadian clock and mice mutated in both genes are arrhythmic. We tested Cry1-/- Cry2-/- mice and fibroblasts derived from t...
متن کاملCyclins and cell cycle checkpoints.
The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase inhibitors, such as p21 and p16, also play important roles in cell cycle control by coordinating internal and external signals and impeding proliferation at several key checkpoints. Understanding how these proteins interac...
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Given that defects in cell cycle control and DNA repair capacity may contribute to tumorigenesis, we hypothesized that patients with lung cancer would be more likely than healthy controls to exhibit deficiencies in cell cycle checkpoints and/or DNA repair capacity as gauged by cellular response to in vitro carcinogen exposure. In an ongoing case-control study of 155 patients with newly diagnose...
متن کاملCell cycle regulation by checkpoints.
Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and hence have been heavily informed by studie...
متن کاملCheckpoints in the Cell Cycle
There are two requirements for successful long-term cell proliferation. One is that the steps of the chromosome replication–division cycle occur in a correct and fixed order: deoxyribonucleic acid (DNA) replication (S phase) always precedes chromosome segregation (mitosis or M phase), followed by cell division (cytokinesis). The second is that this sequence of chromosomal events repeats with a ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2013
ISSN: 1768-3262
DOI: 10.4267/2042/52080