Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus

نویسندگان

چکیده

The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations SLE activity. aim this study to investigate diagnosis, treatment Twenty-eight female patients (17 inactive, 11 active) 10 healthy women were included study. Markers natural killer (Nk), T B cells peripheral blood evaluated by flow cytometry. Nkt decreased only active patients. Activated CD4+, regulatory FoxP3+ both inactive patients, compared control group. data corroborate the disruption immune response suggest phenotipic changes as possible biomarkers

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pregnancy Outcomes in Patients with Systemic Lupus Erythematosus

Background & aim: Pregnant women with systemic lupus erythematosus (SLE) are considered to be at high risk regarding fetal complications and adverse outcomes. The aim of this study was to evaluate the fetal outcomes in pregnant women with the SLE. Methods: This retrospective study was conducted on a total of 125 patients with the SLE referred to the Clinic and Department of Rheumatology of Imam...

متن کامل

Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

متن کامل

Urine chemokines as biomarkers of human systemic lupus erythematosus activity.

The purpose of this study was to evaluate urine monocyte chemoattractant protein-1 (MCP-1) and IL-8 as biomarkers of SLE flare. Urine was collected every 2 mo from patients who were followed prospectively in the Ohio SLE Study. Renal and nonrenal flares were identified and MCP-1 and IL-8 were measured by specific ELISA in samples that were collected at flare. When available, MCP-1 and IL-8 were...

متن کامل

Survival rate of patients with systemic Lupus Erythematosus

Background: Due to infections, cardio-vascular involvement and renal insufficiency, patients with systemic lupus erythematosus live shorter than usual. Objective: To determine the mean survival rate of SLE patients. Patients and Methods: 62 SLE patients admitted in the hospitals of Kerman University of Medical Sciences from 1369 to 1380 were included in this study. The demographic variabl...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Brazilian Journal of Pharmaceutical Sciences

سال: 2023

ISSN: ['2175-9790', '1984-8250']

DOI: https://doi.org/10.1590/s2175-97902023e20052