Cell receptors and cell signalling
نویسندگان
چکیده
منابع مشابه
Clustering, Crosstalk and Signalling of Cell Receptors
We propose a general theory of cooperativity between transmembrane receptors of a cell. Based on a conformation-dependent interaction between nearest-neighboring receptors, the sensitive signalling and the enhancement of clustering, or oligomerization, are explained as two responses to ligand binding. In this model, ligand binding shifts the energy difference between the two conformational stat...
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As a response to ligand binding, transmembrane cell receptors often enhance their clustering, or oligomerization, during the signalling process. Here we present a statistical mechanical model which combines the aspects of clustering and signalling. In this model, receptors float on the surface, while for two neighboring receptors, there is an interaction energy dependent on their conformational...
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T cell activation is a central event in the adaptive immune response and essentially begins with the recognition of an antigenic peptide in the context of a major histocompatibility complex (MHC) on an antigen-presenting cell by the T cell receptor (TCR). The process of T cell activation consists of an orchestration of various functional modules such as actin polymerization, cell surface recept...
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ژورنال
عنوان ژورنال: Molecular Pathology
سال: 2000
ISSN: 1366-8714
DOI: 10.1136/mp.53.6.295