Cell transplantation to replace retinal ganglion cells faces challenges – the Switchboard Dilemma

Allogeneic Transplantation of Müller-Derived Retinal Ganglion Cells Improves Retinal Function in a Feline Model of Ganglion Cell Depletion

Human Müller glia with stem cell characteristics (hMGSCs) have been shown to improve retinal function upon transplantation into rat models of retinal ganglion cell (RGC) depletion. However, their translational potential may depend upon successful engraftment and improvement of retinal function in experimental models with anatomical and functional features resembling those of the human eye. We i...

P129: Use of Stem Cells to Regenerate Degenerative Optic Nerve

Stem cells are undifferentiated cells that have the ability to convert to different types of cells and after dividing, they can produce their own cells or other cells. Axons of the retinal ganglion cells, from the optic nerve. These cells lose the ability to regenerate themselves before birth. Optic nerve degeneration can result from various causes including increased intraocular pressure, comp...

Retinal Ganglion Cells

Segments from adult fish and rat retinae were explanted on myelinmarker expressing oligodendrocytes derived from the regenerating goldfish optic nerve. Fish axons grew in high density and even rat retinal axons regenerated to considerable length on the surface of the fish oligodendrocytes, suggesting that this type of fish glia has axon-growth promoting surface components that exert their influ...

Retinal Ganglion Cells

Retinal Ganglion Cell Death

1.1 Topographic and cellular organization of the retina The retina is the thin (0.2 mm) lining of the back of the eye that gathers light focused on it by the cornea and lens. The retina has a complex laminar organization; cells are organized into layers (Fig. 1). These layers are named by reference to the middle of the eyeball; the innermost layers are located nearest the vitreous chamber, wher...