Cellular and molecular mechanisms of endothelial cell dysfunction.
نویسندگان
چکیده
منابع مشابه
Cellular and molecular mechanisms of endothelial cell dysfunction.
The clinical relevance of the vascular L -arginine/nitric oxide (NO) 1 synthase system to vascular biology lies in the oftrepeated observation that it is altered by a variety of pathophysiological conditions. Such alterations of NO production and/or bioavailability have been shown to occur both in experimental animal models and in human subjects, in the setting of such diverse disorders as hype...
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In healthy individuals, the vascular endothelium regulates an intricate balance of factors that maintain vascular homeostasis and normal arterial function. Functional disruption of the endothelium is known to be an early event that underlies the development of subsequent cardiovascular disease (CVD) including atherosclerosis and coronary heart disease. In addition, the rising global epidemic of...
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The clinical relevance of the vascular L -arginine/nitric oxide (NO) 1 synthase system to vascular biology lies in the oftrepeated observation that it is altered by a variety of pathophysiological conditions. Such alterations of NO production and/or bioavailability have been shown to occur both in experimental animal models and in human subjects, in the setting of such diverse disorders as hype...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1997
ISSN: 0021-9738
DOI: 10.1172/jci119751