Cellular and network mechanisms of electrographic seizures
نویسندگان
چکیده
منابع مشابه
Cellular and network mechanisms of electrographic seizures.
Epileptic seizures constitute a complex multiscale phenomenon that is characterized by synchronized hyperexcitation of neurons in neuronal networks. Recent progress in understanding pathological seizure dynamics provides crucial insights into underlying mechanisms and possible new avenues for the development of novel treatment modalities. Here we review some recent work that combines in vivo ex...
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The absence epilepsies are characterized by recurrent episodes of loss of consciousness associated with generalized spike-and-wave discharges, with an abrupt onset and offset, in the thalamocortical system. In the absence of detailed neurophysiological studies in humans, many of the concepts regarding the pathophysiological basis of absence seizures are based on studies in animal models. Each o...
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PURPOSE To describe the electro-clinical expression of seizures in infants (1-24 months). METHODS We reviewed the video and EEG files of all infantile seizures recorded at Children's Memorial Hospital, Chicago, IL, from 2000 to 2005. Electrographic and clinical features were entered into separate databases. The electrographic component of the database analyzed the predominant location and pat...
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Epileptic seizures are associated with neuronal hyperactivity. Here, however, we investigated whether continuous neuronal firing is necessary to maintain electrographic seizures. We studied a class of "low-Ca2+" ictal epileptiform bursts, induced in rat hippocampal slices, that are characterized by prolonged (2-15 s) interruptions in population spike generation. We found that, during these inte...
متن کاملFocal generation of paroxysmal fast runs during electrographic seizures.
PURPOSE A cortically generated Lennox-Gastaut type seizure is associated with spike-wave/poly-spike-wave discharges at 1.0-2.5 Hz and fast runs at 7-16 Hz. Here we studied the patterns of synchronization during runs of paroxysmal fast spikes. METHODS Electrographic activities were recorded using multisite intracellular and field potential recordings in vivo from cats anesthetized with ketamin...
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ژورنال
عنوان ژورنال: Drug Discovery Today: Disease Models
سال: 2008
ISSN: 1740-6757
DOI: 10.1016/j.ddmod.2008.07.005